차선신(車宣信) 교수
화학ㆍ나노과학과 / 약학부 / 첨단바이오·소재융합전공[대학원]
X-선 결정학(X-ray Crystallography), 초저온 전자현미경(Cryo-EM) 및 계산 구조 생물학 기법을 통합적으로 활용하여 생체 단백질의 고해상도 구조와 기능적 메커니즘을 규명합니다. 이를 통해 근본적인 생명 현상을 원자 수준에서 이해하고, 특히 질병 관련 신약 표적 단백질에 대한 구조 기반 약물 설계(SBDD)를 통해 혁신 신약 개발의 원천 기술을 연구합니다.
- chajung@ewha.ac.kr
- 종합과학관 A동 A412호
- 02-3277-3858
- 연구관심분야
- 구조생물학 (X-선 결정학 & Cryo-EM), 계산 구조 생물학, 단백질 구조 기반 약물 설계, 단백질 구조 기반 생명현상 이해
연구실적
- Regulation of BAP1 activity by novel cancer-associated glutamate residues through ubiquitin binding and PARylation Biochemical and Biophysical Research Communications, 2026, v.797, 153166
- Accelerated Mitochondrial Genome Evolution in Parasitic Barnacles Driven by Adaptive and Non-adaptive Responses MOLECULAR BIOLOGY AND EVOLUTION, 2025, v.42 no.12, msaf303
- Conversion of albumin into a BODIPY-like photosensitizer by a flick reaction, tumor accumulation and photodynamic therapy Biomaterials, 2025, v.313, 122792
- N-terminal helix formation and dimer-monomer transition of FGF10 in specific recognition of FGFR2b FEBS JOURNAL, 2025, v.292 no.24, 6735-6746
- Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss BIOMOLECULES & THERAPEUTICS, 2025, v.33 no.1, 210-220
- Unlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation NUCLEIC ACIDS RESEARCH, 2025, v.53 no.11, gkaf462
- Activation of zinc uptake regulator by zinc binding to three regulatory sites Nucleic Acids Research, 2024, v.52 no.8, 4185-4197
- Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein EXPERIMENTAL AND MOLECULAR MEDICINE, 2024, v.56 no.4, 827-835
- Characterization of the extended substrate spectrum of the class A β-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference International Journal of Antimicrobial Agents, 2024, v.63 no.6, 107171
- Phosphorylation-mediated disassembly of C-terminal binding protein 2 tetramer impedes epigenetic silencing of pluripotency in mouse embryonic stem cells NUCLEIC ACIDS RESEARCH, 2024, v.52 no.22, 13706-13722
- A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction Heliyon, 2023, v.9 no.3, e14039
- An archaeal transcription factor EnfR with a novel ‘eighth note’ fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1 Nucleic Acids Research, 2023, v.51 no.18, 10026-10040
- DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled Advances in Biological Regulation, 2023, v.88, 100943
- Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy THERANOSTICS, 2023, v.13 no.14, 5075-5098
- Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency Scientific Reports, 2023, v.13 no.1, 1005
- Structural and functional characterization of a thermostable secretory phospholipase A2 from Sciscionella marina and its application in liposome biotransformation Acta crystallographica. Section D, Structural biology, 2023, v.79, 188-197
- Targeting BAP1 with small compound inhibitor for colon cancer treatment Scientific Reports, 2023, v.13 no.1, 2264
- Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp JOURNAL OF ANTIBIOTICS, 2022, v.75 no.11, 619-625
- Engineering of a bacterial outer membrane vesicle to a nano-scale reactor for the biodegradation of β-lactam antibiotics Journal of Biotechnology, 2022, v.356, 1-7
- Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity JOURNAL OF MICROBIOLOGY, 2022, v.60 no.11, 1086-1094
- Folic acid pretreatment and its sustained delivery for chondrogenic differentiation of MSCs Journal of Controlled Release, 2022, v.343, 118-130
- Improvement of FGF7 Thermal Stability by Introduction of Mutations in Close Vicinity to Disulfide Bond and Surface Salt Bridge International Journal of Peptide Research and Therapeutics, 2022, v.28 no.3, 85
- Pralatrexate Sustainably Released from Polypeptide Thermogel Is Effective for Chondrogenic Differentiation of Mesenchymal Stem Cells ACS Applied Materials and Interfaces, 2022, v.14 no.3, 3773-3783
- Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp. MARINE DRUGS, 2022, v.20 no.1, 35
- Structural and functional identification of the uncharacterized metallo-β-lactamase superfamily protein TW9814 as a phosphodiesterase with unique metal coordination Acta Crystallographica Section D: Structural Biology, 2022, v.78, 532-541
- The Analyses of Cetacean Virus-Responsive Genes Reveal Evolutionary Marks in Mucosal Immunity-Associated Genes Biochemical Genetics, 2022
- Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp. MARINE DRUGS, 2021, v.19 no.11, 618
- Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against β-lactamases Computational and Structural Biotechnology Journal, 2021, v.19, 145-152
- Dj-1 can replace fgf-2 for long-term culture of human pluripotent stem cells in defined media and feeder-free condition International Journal of Molecular Sciences, 2021, v.22 no.11, 5954
- Gold nanoparticle-assisted SELEX as a visual monitoring platform for the development of small molecule-binding DNA aptasensors Biosensors and Bioelectronics, 2021, v.191, 113468
- Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells CANCERS, 2021, v.13 no.14, 3418
- Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms Nature Communications, 2021, v.12 no.1, 5931
- Structural basis of the cooperative activation of type II citrate synthase (HyCS) from Hymenobacter sp. PAMC 26554 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, v.183, 213-221
- Novel inhibition mechanism of carbapenems on the ACC-1 class C β-lactamase Archives of Biochemistry and Biophysics, 2020, v.693, 108570
- Novel short peptide tag from a bacterial toxin for versatile applications JOURNAL OF IMMUNOLOGICAL METHODS, 2020, v.479, UNSP 112750
- Structural and biochemical analyses of an aminoglycoside 2 '-N-acetyltransferase from Mycolicibacterium smegmatis SCIENTIFIC REPORTS, 2020 , 21503
- Complete reconstitution of the diverse pathways of gentamicin B biosynthesis Nature Chemical Biology, 2019, v.15 no.3, 295-303
- Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, v.63 no.11, e01411-19
- Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H Scientific Reports, 2019, v.9 no.1, 2649
- Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy THERANOSTICS, 2019, v.9 no.22, 6412-6423
- In vitro and in vivo Inhibitory Activity of NADPH Against the AmpC BER Class C beta-Lactamase FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, v.8, 441
- Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, v.107, 1650-1658
- Structural and Biochemical Characterization of the Curcumin-Reducing Activity of CurA from Vibrio vulnificus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, v.66 no.40, 10608-10616
- Structural basis for the interaction between DJ-1 and Bcl-X-L BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, v.495 no.1, 1067-1073
- Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans SCIENTIFIC REPORTS, 2017, v.7
- Biosynthetic pathways of aminoglycosides and their engineering Current Opinion in Biotechnology, 2017, v.48, 33-41
- Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1 ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL, 2017
- GMP and IMP are competitive inhibitors of CMY-10, an extended-spectrum class C β-lactamase Antimicrobial Agents and Chemotherapy, 2017, v.61 no.5
- Genetic and Structural Characterization of a Thermo-Tolerant, Cold-Active, and Acidic Endo-beta-1,4-glucanase from Antarctic Springtail, Cryptopygus antarcticus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, v.65 no.8, 1630-1640
- Genetic and Structural Characterization of a Thermo-Tolerant, Cold-Active, and Acidic Endo-β-1,4-glucanase from Antarctic Springtail, Cryptopygus antarcticus Journal of Agricultural and Food Chemistry, 2017, v.65 no.8, 1630-1640
- Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium Nature Communications, 2017, v.8 no.1
- Structural and mechanistic insights into the inhibition of class C beta-lactamases through the adenylylation of the nucleophilic serine JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, v.72 no.3, 735-743
- Zinc-dependent regulation of zinc import and export genes by Zur NATURE COMMUNICATIONS, 2017, v.8
- Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α Biochemical and Biophysical Research Communications, 2016, v.477 no.2, 181-187
- Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTXVv Microbiology and Immunology, 2016, v.60 no.11, 793-800
- Crystal Structures of Peptide Deformylase from Rice Pathogen Xanthomonas oryzae pv. oryzae in Complex with Substrate Peptides, Actinonin, and Fragment Chemical Compounds JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, v.64 no.39, 7307-7314
- Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase PLOS ONE, 2016, v.11 no.12
- Purification, crystallization, and preliminary X-ray crystallographic analysis of the Group III chaperonin from Carboxydothermus hydrogenoformans JOURNAL OF MICROBIOLOGY, 2016, v.54 no.6, 440-444
- Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C beta-lactamases AmpC BER and CMY-10 ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2016, v.72, 976-985
- Structural basis for the ATP-independent proteolytic activity of LonB proteases and reclassification of their AAA plus modules JOURNAL OF MICROBIOLOGY, 2015, v.53 no.10, 711-717
- The crystal structure of the D-alanine-D-alanine ligase from Acinetobacter baumannii suggests a flexible conformational change in the central domain before nucleotide binding JOURNAL OF MICROBIOLOGY, 2015, v.53 no.11, 776-782
- [학술지논문] Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against beta-lactamases COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, v.19 no.0, 145-152
강의
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2026-2학기
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일반화학Ⅱ
- 학수번호 20417분반 04
- 1학년 (3학점, 3시간) 화 6~6 (종A),목 4~4 (102)
- 자연대, 전자전기1, 지능형반도체1, 건축1, 건도시1, 기후에너지1, 휴기바1, 약학부1, 호크마 / 일반화학과 중복수강 불가
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생화학Ⅱ
- 학수번호 30127분반 01
- 3학년 (3학점, 3시간) 화 4~4 (종A),금 5~5 (102)
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바이오헬스융합화학
- 학수번호 G18687분반 01
- 학년 (3학점, 3시간) 금 4~5 (종D109)
- 영어강의
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2026-1학기
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일반화학Ⅰ
- 학수번호 20416분반 04
- 1학년 (3학점, 3시간) 화 5~5 (종A),목 6~6 (101)
- 자연대,화신공1,식공1,전자전기1,지능형반도체1,기후1,휴기바1,건축1,건도시1,재학생(편입생,복학생,고학번미수강자,호크마,전공결정생 등),일반화학과 중복수강 불가
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생화학Ⅰ
- 학수번호 30126분반 01
- 3학년 (3학점, 3시간) 화 6~6 (종),목 4~4 (101)
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고급생화학
- 학수번호 G12383분반 01
- 학년 (3학점, 3시간) 화 6~7 (종D109)
- 영어강의
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2025-2학기
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일반화학Ⅱ
- 학수번호 20417분반 02
- 1학년 (3학점, 3시간) 화 5~5 (포452),목 6~6 (포452)
- 영어강의 자연대, 전자전기1, 지능형반도체1, 건축1, 건도시1, 기후에너지1, 휴기바1, 호크마 / 일반화학과 중복수강 불가
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생화학Ⅱ
- 학수번호 30127분반 01
- 3학년 (3학점, 3시간) 화 4~4 (종A),금 5~5 (101)
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생체분자공학
- 학수번호 G10155분반 01
- 학년 (3학점, 3시간) 금 4~5 (종D109)
- 영어강의
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하이브리드러닝첨단바이오기술교육
- 학수번호 G18928분반 01
- 학년 (3학점, 3시간) 화 7~8 (약A400)
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2025-1학기
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일반화학Ⅰ
- 학수번호 20416분반 06
- 1학년 (3학점, 3시간) 월 4~4 (종A),목 5~5 (102)
- 영어강의 약학부1만 수강가능
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일반화학실험Ⅰ
- 학수번호 20418분반 03
- 1학년 (1학점, 1.5시간) 수 6~6 (종)
- 자연대, 호크마1, 다음교시까지 진행
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생화학Ⅰ
- 학수번호 30126분반 01
- 3학년 (3학점, 3시간) 월 5~5 (종),수 4~4 (101)
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첨단의약품구조생화학
- 학수번호 G18688분반 01
- 학년 (3학점, 3시간) 수 4~5 (종D109)
- 영어강의
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2024-2학기
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일반화학Ⅱ
- 학수번호 20417분반 01
- 1학년 (3학점, 3시간) 월 5~5 (포465),수 4~4 (포465)
- 영어강의 자연대,화신공1,식공1,호크마1,전자전기1,지능형반도체1,재학생(편입생,복학생,고학번미수강자등),일반화학과 중복수강 불가
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생화학Ⅱ
- 학수번호 30127분반 01
- 3학년 (3학점, 3시간) 월 2~2 (포252),목 3~3 (포252)
- 팀티칭
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바이오헬스융합화학
- 학수번호 G18687분반 01
- 학년 (3학점, 3시간) 목 3~4 (종D106)
- 영어강의
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2024-1학기
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1학년세미나(자연대)
- 학수번호 10851분반 09
- 1학년 (1학점 월 7~7
- 체중 감량 신약 이야기 (비만 치료제)/종A412호
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생화학Ⅰ
- 학수번호 30126분반 01
- 3학년 (3학점, 3시간) 화 3~3 (종),목 2~2 (101)
- 영어강의
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고급화학생물학
- 학수번호 G15647분반 01
- 학년 (3학점, 3시간) 수 5~6 (종D108)
- 시간변경,영어강의
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2023-2학기
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일반화학Ⅱ
- 학수번호 20417분반 02
- 1학년 (3학점, 3시간) 월 5~5 (포453),수 4~4 (포453)
- 영어강의 자연대, 식공1, 화신공1, 환경1, 호크마1, 일반화학과 중복수강 불가
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생화학II 강의 계획서 상세보기
- 학수번호 30127분반 01
- 3학년 (3학점, 3시간) 월 4~4 (종A),목 5~5 (101)
- 팀티칭
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고급생화학
- 학수번호 G12383분반 01
- 학년 (3학점, 3시간) 목 3~4 (종D106)
- 영어강의
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2023-1학기
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호크마세미나 강의 계획서 상세보기
- 학수번호 11302분반 18
- 1학년 (1학점 월 7~7 (종A412)
- 신약 개발의 생화학적 원리
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일반화학I
- 학수번호 20416분반 02
- 1학년 (3학점, 3시간) 화 5~5 (종A),목 6~6 (101)
- 영어강의,ABEEK 자연대, 화신공1, 식공1, 환경1, 호크마1, 컴공1, 기후·에너지1, 일반화학과 중복수강 불가
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생화학I 강의 계획서 상세보기
- 학수번호 30126분반 01
- 3학년 (3학점, 3시간) 화 3~3 (종),목 2~2 (101)
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생화학연구기법
- 학수번호 G12616분반 01
- 학년 (3학점, 3시간) 목 2~3 (종D108)
- 영어강의
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교외수상이력
메디톡스학술상(선도과학자부문) (한국미생물학회)2025-10-27
심계과학상 (포항가속기연구소/한국방사광이용자협회)2022-11-17
최우수논문상 (한국해양과학기술원)2012-12-03
우수신진연구원 (기초기술연구회)2011-12-29
국가연구개발 우수성과 100선 (국가과학기술위원회)2011-11-30
우수논문상 (한국해양과학기술원)2011-10-28
우수업적상 (한국해양과학기술원)2011-01-03
최우수논문상 (한국해양과학기술원)2010-10-30
KRIBB 학술상 (신진과학자부문) (한국미생물학회)2010-10-15
우수강의상 (과학기술연합대학원대학교 (UST))2009-06-23
우수박사학위논문상 (한국분자세포생물학회)2000-10-13
